Organocatalytic Packed-Bed Reactors for the Enantioselective Flow Synthesis of Quaternary Isotetronic Acids by Direct Aldol Reactions of Pyruvates

Organocatalytic Packed-Bed Reactors for the Enantioselective Flow Synthesis of Quaternary Isotetronic Acids by Direct Aldol Reactions of Pyruvates

The utilization of the homogeneous (<i>S</i>)-2-pyrrolidine-tetrazole organocatalyst (Ley catalyst) in the self-condensation of ethyl pyruvate and cross-aldol reactions of ethyl pyruvate donor with non-enolizable pyruvate acceptors, namely the sterically hindered ethyl 3-methyl-2-oxobuty...

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Main Authors: Lorenzo Poletti, Carmela De Risi, Daniele Ragno, Graziano Di Carmine, Riccardo Tassoni, Alessandro Massi, Paolo Dambruoso
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
flow chemistry
organocatalysis
aldol reaction
butenolides
pyruvates
Online Access:https://www.mdpi.com/1420-3049/30/2/296
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