The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
Aims. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR) susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic. Methods. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science,...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/805801 |
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| author | Liyuan Han Lina Zhang Wenhua Xing Renjie Zhuo XiaLu Lin Yanhua Hao Qunhong Wu Jinshun Zhao |
| author_facet | Liyuan Han Lina Zhang Wenhua Xing Renjie Zhuo XiaLu Lin Yanhua Hao Qunhong Wu Jinshun Zhao |
| author_sort | Liyuan Han |
| collection | DOAJ |
| description | Aims. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR) susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic. Methods. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Cochrane Library with the last report up to January 10, 2014. ORs and 95% CIs were calculated for VEGF–2578C/A (rs699947), –1154G/A (rs1570360), –460T/C (rs833061), −634G>C (rs2010963), and +936C/T (rs3025039) in at least two published studies. Meta-analysis was performed in a fixed/random effect model by using the software STATA 12.0. Results. A total of 11 studies fulfilling the inclusion criteria were included in this meta-analysis. A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20–8.41, and P(z)=0.01) in Asian and overall populations, while a significant association was also found between –460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12–4.01, and P(z)=0.02). Conclusions. Our meta-analysis demonstrates that +936C/T (rs3025039) is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of –460T/C (rs833061) is associated with elevated DR susceptibility. |
| format | Article |
| id | doaj-art-180a90ae97fd4ad7addde60d15b72444 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-180a90ae97fd4ad7addde60d15b724442025-02-03T01:23:48ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/805801805801The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control StudiesLiyuan Han0Lina Zhang1Wenhua Xing2Renjie Zhuo3XiaLu Lin4Yanhua Hao5Qunhong Wu6Jinshun Zhao7Department of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, ChinaDepartment of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, ChinaDepartment of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, ChinaDepartment of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, ChinaDepartment of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, ChinaDepartment of Social Medicine, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang Province 150081, ChinaDepartment of Social Medicine, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang Province 150081, ChinaDepartment of Preventive Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo 315211, ChinaAims. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR) susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic. Methods. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Cochrane Library with the last report up to January 10, 2014. ORs and 95% CIs were calculated for VEGF–2578C/A (rs699947), –1154G/A (rs1570360), –460T/C (rs833061), −634G>C (rs2010963), and +936C/T (rs3025039) in at least two published studies. Meta-analysis was performed in a fixed/random effect model by using the software STATA 12.0. Results. A total of 11 studies fulfilling the inclusion criteria were included in this meta-analysis. A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20–8.41, and P(z)=0.01) in Asian and overall populations, while a significant association was also found between –460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12–4.01, and P(z)=0.02). Conclusions. Our meta-analysis demonstrates that +936C/T (rs3025039) is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of –460T/C (rs833061) is associated with elevated DR susceptibility.http://dx.doi.org/10.1155/2014/805801 |
| spellingShingle | Liyuan Han Lina Zhang Wenhua Xing Renjie Zhuo XiaLu Lin Yanhua Hao Qunhong Wu Jinshun Zhao The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies Journal of Diabetes Research |
| title | The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies |
| title_full | The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies |
| title_fullStr | The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies |
| title_full_unstemmed | The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies |
| title_short | The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies |
| title_sort | associations between vegf gene polymorphisms and diabetic retinopathy susceptibility a meta analysis of 11 case control studies |
| url | http://dx.doi.org/10.1155/2014/805801 |
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