Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance

Abstract Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insulin sensitivity. An obesity‐promoting high‐fat diet (H...

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Main Authors: Emmanuel Denou, Karine Lolmède, Lucile Garidou, Celine Pomie, Chantal Chabo, Trevor C Lau, Morgan D Fullerton, Giulia Nigro, Alexia Zakaroff‐Girard, Elodie Luche, Céline Garret, Matteo Serino, Jacques Amar, Michael Courtney, Joseph F Cavallari, Brandyn D Henriksbo, Nicole G Barra, Kevin P Foley, Joseph B McPhee, Brittany M Duggan, Hayley M O'Neill, Amanda J Lee, Philippe Sansonetti, Ali A Ashkar, Waliul I Khan, Michael G Surette, Anne Bouloumié, Gregory R Steinberg, Rémy Burcelin, Jonathan D Schertzer
Format: Article
Language:English
Published: Springer Nature 2015-02-01
Series:EMBO Molecular Medicine
Subjects:
diabetes
glucose
metabolic inflammation
microbiome
obesity
Online Access:https://doi.org/10.15252/emmm.201404169
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https://doi.org/10.15252/emmm.201404169

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