Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity
Prior studies indicate that applying low-intensity transcranial ultrasound stimulation (TUS) to the hippocampus can suppress epileptic seizures. Nevertheless, it is unclear how TUS regulates hippocampal neural activity, and whether and how epileptic discharges in the motor cortex are suppressed by m...
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IEEE
2025-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
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| Online Access: | https://ieeexplore.ieee.org/document/10820872/ |
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| author | Na Pang Qianqian Wang Jiamin Pei Hailin Zhang Yi Yuan Jiaqing Yan |
| author_facet | Na Pang Qianqian Wang Jiamin Pei Hailin Zhang Yi Yuan Jiaqing Yan |
| author_sort | Na Pang |
| collection | DOAJ |
| description | Prior studies indicate that applying low-intensity transcranial ultrasound stimulation (TUS) to the hippocampus can suppress epileptic seizures. Nevertheless, it is unclear how TUS regulates hippocampal neural activity, and whether and how epileptic discharges in the motor cortex are suppressed by modulating hippocampal neural activity. To explore the answers of above questions, ultrasound was utilized to investigate the responses to the aforementioned inquiries by stimulating the hippocampus of mice with penicillin-induced epilepsy, while simultaneously recording the local field potentials (LFPs) in the hippocampus and the motor cortex (M1) throughout the experiment. The results showed that TUS: 1) reduced the amplitude and the strength of the <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\theta } $ </tex-math></inline-formula> frequency band in LFPs in the hippocampus and M1; 2) decreased the coupling strength of the <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\delta }$ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma } $ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\theta } $ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma }$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\alpha } $ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma } $ </tex-math></inline-formula> frequency bands in the hippocampus and M1; and 3) weakened the correlation of neural activity between the hippocampus and M1. The above results indicated that TUS effectively suppressed abnormal slow neural oscillations in the hippocampus, had a significant decoupling effect on slow-fast neural oscillations, and reduced the correlation of hippocampus-cortical neural activity. TUS of the hippocampus may be through the hippocampus-cortical circuits to suppress abnormal neural firing activity in M1. |
| format | Article |
| id | doaj-art-17f2d4c2d7c540448e3c8710d80182dd |
| institution | Kabale University |
| issn | 1534-4320 1558-0210 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IEEE |
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| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj-art-17f2d4c2d7c540448e3c8710d80182dd2025-01-21T00:00:10ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1534-43201558-02102025-01-013336637110.1109/TNSRE.2025.352551610820872Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural ActivityNa Pang0Qianqian Wang1Jiamin Pei2Hailin Zhang3Yi Yuan4https://orcid.org/0000-0002-8951-810XJiaqing Yan5Postdoctoral Research Station of Basic Medicine, Hebei Medical University, Shijiazhuang, ChinaSchool of Electrical Engineering and the Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, Yanshan University, Qinhuangdao, ChinaSchool of Electrical Engineering and the Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, Yanshan University, Qinhuangdao, ChinaDepartment of Pharmacology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education, and the Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Medical University, Shijiazhuang, Hebei, ChinaSchool of Electrical Engineering and the Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, Yanshan University, Qinhuangdao, ChinaCollege of Electrical and Control Engineering, North China University of Technology, Beijing, ChinaPrior studies indicate that applying low-intensity transcranial ultrasound stimulation (TUS) to the hippocampus can suppress epileptic seizures. Nevertheless, it is unclear how TUS regulates hippocampal neural activity, and whether and how epileptic discharges in the motor cortex are suppressed by modulating hippocampal neural activity. To explore the answers of above questions, ultrasound was utilized to investigate the responses to the aforementioned inquiries by stimulating the hippocampus of mice with penicillin-induced epilepsy, while simultaneously recording the local field potentials (LFPs) in the hippocampus and the motor cortex (M1) throughout the experiment. The results showed that TUS: 1) reduced the amplitude and the strength of the <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\theta } $ </tex-math></inline-formula> frequency band in LFPs in the hippocampus and M1; 2) decreased the coupling strength of the <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\delta }$ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma } $ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\theta } $ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma }$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\alpha } $ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma } $ </tex-math></inline-formula> frequency bands in the hippocampus and M1; and 3) weakened the correlation of neural activity between the hippocampus and M1. The above results indicated that TUS effectively suppressed abnormal slow neural oscillations in the hippocampus, had a significant decoupling effect on slow-fast neural oscillations, and reduced the correlation of hippocampus-cortical neural activity. TUS of the hippocampus may be through the hippocampus-cortical circuits to suppress abnormal neural firing activity in M1.https://ieeexplore.ieee.org/document/10820872/Low-intensity transcranial ultrasound stimulationepilepsyhippocampus-cortical circuitneural activitylocal field potential |
| spellingShingle | Na Pang Qianqian Wang Jiamin Pei Hailin Zhang Yi Yuan Jiaqing Yan Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity IEEE Transactions on Neural Systems and Rehabilitation Engineering Low-intensity transcranial ultrasound stimulation epilepsy hippocampus-cortical circuit neural activity local field potential |
| title | Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity |
| title_full | Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity |
| title_fullStr | Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity |
| title_full_unstemmed | Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity |
| title_short | Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity |
| title_sort | low intensity transcranial ultrasound stimulation inhibits epileptic seizures in motor cortex by modulating hippocampus neural activity |
| topic | Low-intensity transcranial ultrasound stimulation epilepsy hippocampus-cortical circuit neural activity local field potential |
| url | https://ieeexplore.ieee.org/document/10820872/ |
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