TLS and immune cell profiling: immunomodulatory effects of immunochemotherapy on tumor microenvironment in resectable stage III NSCLC

TLS and immune cell profiling: immunomodulatory effects of immunochemotherapy on tumor microenvironment in resectable stage III NSCLC

BackgroundThe use of programmed death-1 (PD-1) inhibitors in the neoadjuvant setting for patients with resectable stage III NSCLC has revolutionized this field in recent years. However, there is still 40%-60% of patients do not benefit from this approach. The complex interactions between immune cell...

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Bibliographic Details
Main Authors: Chaopin Yang, Jinqi You, Yizhi Wang, Si Chen, Yan Tang, Hao Chen, Haoran Zhong, Ruyue Song, Hao Long, Tong Xiang, Ze-Rui Zhao, Jianchuan Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
NSCLC
immunochemotherapy
tertiary lymphoid structures (TLSs)
the axis of PD-L1+CD11c+ cells and PD1+CD8+ T cells
CCR7+CD4+ T cells
CD38+CD8+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1499731/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1499731/full

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