Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1‐7) Alone is Insufficient

Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1‐7) Alone is Insufficient

ABSTRACT ACE2 has shown effectiveness in treating pulmonary hypertension in multiple animal models and has some promise in early human trials. The key barrier to translation is that enzymatically active ACE2 is difficult to manufacture and exhibits a short half‐life in humans, making chronic adminis...

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Main Authors: James West, Megha Talati, Erica Carrier, Anandharajan Rathinasabapathy, Ibragim Gaidarov, Benjamin Vigl, Ying Cai, Hongpeng Jia, Tom Blackwell, Santhi Gladson, Christie Moore, Sheila Shay, Ethan Sevier, Anna Hemnes
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1002/pul2.70083
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https://doi.org/10.1002/pul2.70083

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