Aura phenomenon: a proposal for an etiology-based clinical classification
Abstract Background The term “aura” refers to a well-defined pattern of usually positive, progressive, and reversible neurological symptoms, with spreading depolarization as the underlying mechanism. While commonly associated with migraine, aura can also occur in other neurological disorders (i.e.,...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | The Journal of Headache and Pain |
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| Online Access: | https://doi.org/10.1186/s10194-024-01943-8 |
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| author | Umberto Pensato Andrew M. Demchuk Jens P. Dreier Kevin C. Brennan Simona Sacco Michele Romoli |
| author_facet | Umberto Pensato Andrew M. Demchuk Jens P. Dreier Kevin C. Brennan Simona Sacco Michele Romoli |
| author_sort | Umberto Pensato |
| collection | DOAJ |
| description | Abstract Background The term “aura” refers to a well-defined pattern of usually positive, progressive, and reversible neurological symptoms, with spreading depolarization as the underlying mechanism. While commonly associated with migraine, aura can also occur in other neurological disorders (i.e., cerebrovascular disorders). However, current terminology inadequately describes its different underlying clinical etiologies. Main body We propose the following terminology and etiology-based clinical classification for the aura phenomenon: (i) Migrainous Aura (when the etiology is migraine), (ii) Non-migrainous Aura (when there is an alternative etiology), (iii) Aura of uncertain clinical etiology (when etiology is unclear), and (iv) Migrainous Infarction (a typical migrainous aura in a patient with migraine with aura associated with an infarction in a corresponding anatomical brain region). Conclusion This nuanced classification aims to aid in the diagnostic evaluation and phenotyping of aura phenomenon, ultimately improving the diagnosis and management of the different associated neurological conditions. Moreover, it could promote effective communication and translational mechanistic research. |
| format | Article |
| id | doaj-art-1766ca6db5eb43d6a7561946d98c0b50 |
| institution | Kabale University |
| issn | 1129-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj-art-1766ca6db5eb43d6a7561946d98c0b502025-01-19T12:33:15ZengBMCThe Journal of Headache and Pain1129-23772025-01-012611910.1186/s10194-024-01943-8Aura phenomenon: a proposal for an etiology-based clinical classificationUmberto Pensato0Andrew M. Demchuk1Jens P. Dreier2Kevin C. Brennan3Simona Sacco4Michele Romoli5Department of Biomedical Sciences, Humanitas UniversityCalgary Stroke Program, Depts of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of CalgaryCenter for Stroke Research, Charité University Medicine BerlinDepartment of Neurology, University of UtahDepartment of Applied Clinical Sciences and Biotechnology, University of L’AquilaDepartment of Neuroscience, Bufalini Hospital, AUSL RomagnaAbstract Background The term “aura” refers to a well-defined pattern of usually positive, progressive, and reversible neurological symptoms, with spreading depolarization as the underlying mechanism. While commonly associated with migraine, aura can also occur in other neurological disorders (i.e., cerebrovascular disorders). However, current terminology inadequately describes its different underlying clinical etiologies. Main body We propose the following terminology and etiology-based clinical classification for the aura phenomenon: (i) Migrainous Aura (when the etiology is migraine), (ii) Non-migrainous Aura (when there is an alternative etiology), (iii) Aura of uncertain clinical etiology (when etiology is unclear), and (iv) Migrainous Infarction (a typical migrainous aura in a patient with migraine with aura associated with an infarction in a corresponding anatomical brain region). Conclusion This nuanced classification aims to aid in the diagnostic evaluation and phenotyping of aura phenomenon, ultimately improving the diagnosis and management of the different associated neurological conditions. Moreover, it could promote effective communication and translational mechanistic research.https://doi.org/10.1186/s10194-024-01943-8Migraine with auraMigrainous infarctionMigrainous auraStrokeCortical spreading depression |
| spellingShingle | Umberto Pensato Andrew M. Demchuk Jens P. Dreier Kevin C. Brennan Simona Sacco Michele Romoli Aura phenomenon: a proposal for an etiology-based clinical classification The Journal of Headache and Pain Migraine with aura Migrainous infarction Migrainous aura Stroke Cortical spreading depression |
| title | Aura phenomenon: a proposal for an etiology-based clinical classification |
| title_full | Aura phenomenon: a proposal for an etiology-based clinical classification |
| title_fullStr | Aura phenomenon: a proposal for an etiology-based clinical classification |
| title_full_unstemmed | Aura phenomenon: a proposal for an etiology-based clinical classification |
| title_short | Aura phenomenon: a proposal for an etiology-based clinical classification |
| title_sort | aura phenomenon a proposal for an etiology based clinical classification |
| topic | Migraine with aura Migrainous infarction Migrainous aura Stroke Cortical spreading depression |
| url | https://doi.org/10.1186/s10194-024-01943-8 |
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