A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice

A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice

Summary: Dengue virus (DENV) is a mosquito-transmitted flavivirus; there are four serotypes (DENV1-4) that co-circulate globally. Primary infection causes self-limiting febrile illness, but secondary infection by a heterologous serotype can predispose to severe dengue. Neutralizing antibodies are ke...

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Bibliographic Details
Main Authors: Margarette C. Mariano, Helen S. Jung, Olivia Vergnolle, Keith Haskell, Lamount R. Evanson, Gregory Quevedo, Julia C. Frei, Karen Tong, Larissa B. Thackray, Michael S. Diamond, Jonathan R. Lai
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Natural sciences
Chemistry
Biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007953
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http://www.sciencedirect.com/science/article/pii/S2589004225007953

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