From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features
Abstract Dedifferentiated liposarcoma (DDLPS) with inflammatory myofibroblastic tumor (IMT)-like features is a rare and diagnostically challenging variant of soft tissue sarcoma. We report the case of a 74-year-old man who presented with a mesenteric mass in 2022 and recurrent tumors in 2024. Tissue...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Diagnostic Pathology |
| Online Access: | https://doi.org/10.1186/s13000-025-01640-3 |
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| author | Simon Schallenberg Miriam Schulte Mihnea P. Dragomir Armin Jarosch Wolfgang Hartmann Eva Wardelmann |
| author_facet | Simon Schallenberg Miriam Schulte Mihnea P. Dragomir Armin Jarosch Wolfgang Hartmann Eva Wardelmann |
| author_sort | Simon Schallenberg |
| collection | DOAJ |
| description | Abstract Dedifferentiated liposarcoma (DDLPS) with inflammatory myofibroblastic tumor (IMT)-like features is a rare and diagnostically challenging variant of soft tissue sarcoma. We report the case of a 74-year-old man who presented with a mesenteric mass in 2022 and recurrent tumors in 2024. Tissue from both primary and recurrent tumors were submitted to our reference center for pathological reevaluation, with a suspicion of IMT being suspected. Although the tumors exhibited morphological characteristics consistent with those observed in IMT, they displayed distinctive histological, immunohistochemical and molecular features suggestive of DDLPS with IMT-like features, including amplification of the MDM2 gene. This report highlights the morphological spectrum of DDLPS, the diagnostic role of molecular pathology, and the importance of differentiating this aggressive neoplasm from benign entities such as IMT. |
| format | Article |
| id | doaj-art-16fdba2d607647f987b77da730b51e8a |
| institution | OA Journals |
| issn | 1746-1596 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj-art-16fdba2d607647f987b77da730b51e8a2025-08-20T02:11:55ZengBMCDiagnostic Pathology1746-15962025-04-012011610.1186/s13000-025-01640-3From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like featuresSimon Schallenberg0Miriam Schulte1Mihnea P. Dragomir2Armin Jarosch3Wolfgang Hartmann4Eva Wardelmann5Institute of Pathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu BerlinGerhard-Domagk-Institut Für Pathologie, Universitätsklinikum MünsterInstitute of Pathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu BerlinInstitute of Pathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu BerlinGerhard-Domagk-Institut Für Pathologie, Universitätsklinikum MünsterGerhard-Domagk-Institut Für Pathologie, Universitätsklinikum MünsterAbstract Dedifferentiated liposarcoma (DDLPS) with inflammatory myofibroblastic tumor (IMT)-like features is a rare and diagnostically challenging variant of soft tissue sarcoma. We report the case of a 74-year-old man who presented with a mesenteric mass in 2022 and recurrent tumors in 2024. Tissue from both primary and recurrent tumors were submitted to our reference center for pathological reevaluation, with a suspicion of IMT being suspected. Although the tumors exhibited morphological characteristics consistent with those observed in IMT, they displayed distinctive histological, immunohistochemical and molecular features suggestive of DDLPS with IMT-like features, including amplification of the MDM2 gene. This report highlights the morphological spectrum of DDLPS, the diagnostic role of molecular pathology, and the importance of differentiating this aggressive neoplasm from benign entities such as IMT.https://doi.org/10.1186/s13000-025-01640-3 |
| spellingShingle | Simon Schallenberg Miriam Schulte Mihnea P. Dragomir Armin Jarosch Wolfgang Hartmann Eva Wardelmann From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features Diagnostic Pathology |
| title | From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features |
| title_full | From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features |
| title_fullStr | From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features |
| title_full_unstemmed | From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features |
| title_short | From benign appearance to malignant truth: a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features |
| title_sort | from benign appearance to malignant truth a case report of mesenteric dedifferentiated liposarcoma with inflammatory myofibroblastic tumor like features |
| url | https://doi.org/10.1186/s13000-025-01640-3 |
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