Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review
A comprehensive review of known uremic retention molecules goes back to more than 10 years ago and did not consider metabolomic analyses. The present analysis searches for as of yet unclassified solutes retained in chronic kidney disease (CKD) by analyzing metabolites associated with relevant outcom...
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| Format: | Article |
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Elsevier
2025-03-01
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| Series: | Kidney Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059524001663 |
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| author | Raymond Vanholder Griet Glorieux Angel Argiles Stéphane Burtey Gerald Cohen Flore Duranton Laetitia Koppe Ziad A. Massy Alberto Ortiz Rosalinde Masereeuw Dimitrios Stamatialis Joachim Jankowski |
| author_facet | Raymond Vanholder Griet Glorieux Angel Argiles Stéphane Burtey Gerald Cohen Flore Duranton Laetitia Koppe Ziad A. Massy Alberto Ortiz Rosalinde Masereeuw Dimitrios Stamatialis Joachim Jankowski |
| author_sort | Raymond Vanholder |
| collection | DOAJ |
| description | A comprehensive review of known uremic retention molecules goes back to more than 10 years ago and did not consider metabolomic analyses. The present analysis searches for as of yet unclassified solutes retained in chronic kidney disease (CKD) by analyzing metabolites associated with relevant outcomes of CKD. This untargeted metabolomics-based approach is compared with a conventional targeted literature search. For the selected molecules, the literature was screened for arguments regarding toxic (harmful), beneficial, or neutral effects in experimental or clinical studies. Findings were independently crosschecked. In total, 103 molecules were selected. No literature on any effect was found for 55 substances, 3 molecules had no significant effect, and 13 others showed beneficial effects. For the remaining 32 compounds, we found at least one report of a toxic effect. Whereas 62.5% of the compounds with at least one study on a toxic effect was retrieved via the bottom-up approach, 69.2% of the substances originating from metabolomics-based approaches showed a beneficial effect. Our results suggest that untargeted metabolomics offer a more balanced view of uremic retention than the targeted approaches, with higher chances of revealing the beneficial potential of some of the metabolites. |
| format | Article |
| id | doaj-art-16d52e1baf81484e933f8f581c1817f9 |
| institution | Kabale University |
| issn | 2590-0595 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj-art-16d52e1baf81484e933f8f581c1817f92025-02-02T05:29:13ZengElsevierKidney Medicine2590-05952025-03-0173100955Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature ReviewRaymond Vanholder0Griet Glorieux1Angel Argiles2Stéphane Burtey3Gerald Cohen4Flore Duranton5Laetitia Koppe6Ziad A. Massy7Alberto Ortiz8Rosalinde Masereeuw9Dimitrios Stamatialis10Joachim Jankowski11Nephrology Section, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium; Address for Correspondence: Raymond Vanholder, MD, PhD, Nephrology Section, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Steenhuisdreef, 27, Drongen 9031, Belgium.Nephrology Section, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, BelgiumRD Néphrologie, Montpellier, France; Néphrologie Dialyse Saint Guilhem, Sète, FranceC2VN, Aix-Marseille Université, INSERM, INRAE, Marseille, FranceDepartment of Nephrology and Dialysis, Medical University of Vienna, Vienna, AustriaRD Néphrologie, Montpellier, FranceDepartment of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Université de Lyon, Lyon, France; CarMeN lab, INSERM U1060, Université Claude Bernard Lyon 1, FranceInserm Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University (UPS), Villejuif, France; Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France; Department of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, FranceDepartment of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain; RICORS2040, Madrid, SpainDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsAdvanced Organ Bioengineering and Therapeutics, Technical Medical Centre, Faculty of Science and Technology, University of Twente, Enschede, The NetherlandsInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University, Aachen, Germany; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The NetherlandsA comprehensive review of known uremic retention molecules goes back to more than 10 years ago and did not consider metabolomic analyses. The present analysis searches for as of yet unclassified solutes retained in chronic kidney disease (CKD) by analyzing metabolites associated with relevant outcomes of CKD. This untargeted metabolomics-based approach is compared with a conventional targeted literature search. For the selected molecules, the literature was screened for arguments regarding toxic (harmful), beneficial, or neutral effects in experimental or clinical studies. Findings were independently crosschecked. In total, 103 molecules were selected. No literature on any effect was found for 55 substances, 3 molecules had no significant effect, and 13 others showed beneficial effects. For the remaining 32 compounds, we found at least one report of a toxic effect. Whereas 62.5% of the compounds with at least one study on a toxic effect was retrieved via the bottom-up approach, 69.2% of the substances originating from metabolomics-based approaches showed a beneficial effect. Our results suggest that untargeted metabolomics offer a more balanced view of uremic retention than the targeted approaches, with higher chances of revealing the beneficial potential of some of the metabolites.http://www.sciencedirect.com/science/article/pii/S2590059524001663Chronic kidney diseasemetabolomicstoxicityuremic toxin |
| spellingShingle | Raymond Vanholder Griet Glorieux Angel Argiles Stéphane Burtey Gerald Cohen Flore Duranton Laetitia Koppe Ziad A. Massy Alberto Ortiz Rosalinde Masereeuw Dimitrios Stamatialis Joachim Jankowski Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review Kidney Medicine Chronic kidney disease metabolomics toxicity uremic toxin |
| title | Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review |
| title_full | Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review |
| title_fullStr | Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review |
| title_full_unstemmed | Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review |
| title_short | Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review |
| title_sort | metabolomics to identify unclassified uremic toxins a comprehensive literature review |
| topic | Chronic kidney disease metabolomics toxicity uremic toxin |
| url | http://www.sciencedirect.com/science/article/pii/S2590059524001663 |
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