Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen
Background. Acetaminophen (APAP) is a commonly used analgesic and antipyretic. When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammato...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/196598 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562719431065600 |
|---|---|
| author | Bruno da Cruz Pádua Joamyr Victor Rossoni Júnior Cíntia Lopes de Brito Magalhães Míriam Martins Chaves Marcelo Eustáquio Silva Maria Lucia Pedrosa Gustavo Henrique Bianco de Souza Geraldo Célio Brandão Ivanildes Vasconcelos Rodrigues Wanderson Geraldo Lima Daniela Caldeira Costa |
| author_facet | Bruno da Cruz Pádua Joamyr Victor Rossoni Júnior Cíntia Lopes de Brito Magalhães Míriam Martins Chaves Marcelo Eustáquio Silva Maria Lucia Pedrosa Gustavo Henrique Bianco de Souza Geraldo Célio Brandão Ivanildes Vasconcelos Rodrigues Wanderson Geraldo Lima Daniela Caldeira Costa |
| author_sort | Bruno da Cruz Pádua |
| collection | DOAJ |
| description | Background. Acetaminophen (APAP) is a commonly used analgesic and antipyretic. When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose. Methods. The present study attempted to investigate the protective effect of B. trimera against APAP-induced hepatic damage in rats. The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined. Results. The pretreatment with B. trimera attenuated serum activities of ALT and AST that were enhanced by administration of APAP. Furthermore, pretreatment with the extract decreases the activity of the enzyme SOD and increases the activity of catalase and the concentration of total glutathione. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by APAP. Conclusions. The hepatoprotective action of B. trimera extract may rely on its effect on reducing the oxidative stress caused by APAP-induced hepatic damage in a rat model. General Significance. These results make the extract of B. trimera a potential candidate drug capable of protecting the liver against damage caused by APAP overdose. |
| format | Article |
| id | doaj-art-16ce7f1664a74c2ebafc42d1a162a929 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-16ce7f1664a74c2ebafc42d1a162a9292025-02-03T01:21:54ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/196598196598Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by AcetaminophenBruno da Cruz Pádua0Joamyr Victor Rossoni Júnior1Cíntia Lopes de Brito Magalhães2Míriam Martins Chaves3Marcelo Eustáquio Silva4Maria Lucia Pedrosa5Gustavo Henrique Bianco de Souza6Geraldo Célio Brandão7Ivanildes Vasconcelos Rodrigues8Wanderson Geraldo Lima9Daniela Caldeira Costa10Programa de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilPrograma de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilPrograma de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Cx. Postal 486, 30.161-970 Belo Horizonte, MG, BrazilPrograma de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilPrograma de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilPrograma de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Escola de Farmácia, Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilPrograma de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Escola de Farmácia, Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilNúcleo de Pesquisas em Produtos Naturais e Sintéticos, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirao Preto, Universidade de São Paulo (USP), 14040-903 São Paulo, SP, BrazilPrograma de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilPrograma de Pós-graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto (UFOP), 35.400-000 Ouro Preto, MG, BrazilBackground. Acetaminophen (APAP) is a commonly used analgesic and antipyretic. When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose. Methods. The present study attempted to investigate the protective effect of B. trimera against APAP-induced hepatic damage in rats. The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined. Results. The pretreatment with B. trimera attenuated serum activities of ALT and AST that were enhanced by administration of APAP. Furthermore, pretreatment with the extract decreases the activity of the enzyme SOD and increases the activity of catalase and the concentration of total glutathione. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by APAP. Conclusions. The hepatoprotective action of B. trimera extract may rely on its effect on reducing the oxidative stress caused by APAP-induced hepatic damage in a rat model. General Significance. These results make the extract of B. trimera a potential candidate drug capable of protecting the liver against damage caused by APAP overdose.http://dx.doi.org/10.1155/2014/196598 |
| spellingShingle | Bruno da Cruz Pádua Joamyr Victor Rossoni Júnior Cíntia Lopes de Brito Magalhães Míriam Martins Chaves Marcelo Eustáquio Silva Maria Lucia Pedrosa Gustavo Henrique Bianco de Souza Geraldo Célio Brandão Ivanildes Vasconcelos Rodrigues Wanderson Geraldo Lima Daniela Caldeira Costa Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen Mediators of Inflammation |
| title | Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen |
| title_full | Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen |
| title_fullStr | Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen |
| title_full_unstemmed | Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen |
| title_short | Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen |
| title_sort | protective effect of baccharis trimera extract on acute hepatic injury in a model of inflammation induced by acetaminophen |
| url | http://dx.doi.org/10.1155/2014/196598 |
| work_keys_str_mv | AT brunodacruzpadua protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT joamyrvictorrossonijunior protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT cintialopesdebritomagalhaes protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT miriammartinschaves protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT marceloeustaquiosilva protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT marialuciapedrosa protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT gustavohenriquebiancodesouza protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT geraldoceliobrandao protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT ivanildesvasconcelosrodrigues protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT wandersongeraldolima protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen AT danielacaldeiracosta protectiveeffectofbaccharistrimeraextractonacutehepaticinjuryinamodelofinflammationinducedbyacetaminophen |