Microcephaly protein ANKLE2 promotes Zika virus replication

Microcephaly protein ANKLE2 promotes Zika virus replication

ABSTRACT Orthoflaviviruses are positive-sense single-stranded RNA viruses that hijack host proteins to promote their own replication. Zika virus (ZIKV) is infamous among orthoflaviviruses for its association with severe congenital birth defects, notably microcephaly. We previously mapped ZIKV-host p...

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Bibliographic Details
Main Authors: Adam T. Fishburn, Cole J. Florio, Thomas N. Klaessens, Brian Prince, Neil A. B. Adia, Nicholas J. Lopez, Nitin Sai Beesabathuni, Sydney S. Becker, Liubov Cherkashchenko, Sophia T. Haggard Arcé, Vivian Hoang, Traci N. Shiu, R. Blake Richardson, Matthew J. Evans, Claudia Rückert, Priya S. Shah
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
Zika virus
orthoflavivirus
NS4A
ANKLE2
virus-host interaction
microcephaly
Online Access:https://journals.asm.org/doi/10.1128/mbio.02683-24
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