miR‐4448/Girdin/Akt/AMPK axis inhibits EZH2‐mediated EMT and tumorigenesis in small‐cell lung cancer

miR‐4448/Girdin/Akt/AMPK axis inhibits EZH2‐mediated EMT and tumorigenesis in small‐cell lung cancer

Abstract Background Small‐cell lung cancer (SCLC) shows high enhancer of zeste homolog 2 (EZH2) expressions. EZH2‐mediated epigenetics promote epithelial‐mesenchymal transition (EMT), enhancing invasive and metastatic potential in malignancies. MicroRNAs (miRNAs), small noncoding RNAs, modulate EMT,...

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Bibliographic Details
Main Authors: Nobuyuki Koyama, Yuichi Ishikawa, Hiromitsu Ohta, Takuya Aoki, Hiroyuki Kyoyama, Kazutetsu Aoshiba, Kazutsugu Uematsu
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Cancer Medicine
Subjects:
Akt
AMP‐activated protein kinase
epithelial‐mesenchymal transition
enhancer of zeste homolog 2
Girdin
miR‐4448
Online Access:https://doi.org/10.1002/cam4.70093
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