Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection.

Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection.

HIV-1 replication within the central nervous system (CNS) impairs neurocognitive function and has the potential to establish persistent, compartmentalized viral reservoirs. The origins of HIV-1 detected in the CNS compartment are unknown, including whether cells within the cerebrospinal fluid (CSF)...

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Main Authors: Vishakha Sharma, Matthew Creegan, Andrey Tokarev, Denise Hsu, Bonnie M Slike, Carlo Sacdalan, Phillip Chan, Serena Spudich, Jintanat Ananworanich, Michael A Eller, Shelly J Krebs, Sandhya Vasan, Diane L Bolton, RV254/SEARCH010 and RV304/SEARCH013 Study Teams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010105&type=printable
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