Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism

Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism

Alzheimer's disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher risk of AD in women. Metabolic pathways have been implicated in AD progression, but studies to date...

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Main Authors: Rocio Diaz Escarcega, Vijay Kumar M. J., Vasilia E. Kyriakopoulos, Guadalupe J. Ortiz, Aaron M. Gusdon, Huihui Fan, Pedram Peesh, Maria P. Blasco Conesa, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Stella H. Kim, Miriam Hinojosa, Christine M. Farrell, Sean P. Marrelli, Akihiko Urayama, Bhanu P. Ganesh, Paul E. Schulz, Louise D. McCullough, Andrey S. Tsvetkov
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neurobiology of Disease
Subjects:
Sex differences
Cognition
Metabolomics
Lipids
1-Monoacylglycerol
Sphingosine kinase 2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003498
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