Predicting drug–drug interactions and optimal dosing of betrixaban with physiologically based pharmacokinetic modeling in patients with renal impairment who were coadministered with P-glycoprotein inhibitors
Objective To optimize dosing adjustments in patients with renal impairment who were coadministered with P-glycoprotein inhibitors—verapamil or amiodarone—using a physiologically based pharmacokinetic model. Methods The developed physiologically based pharmacokinetic model was corroborated using prev...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605251346587 |
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