Personalised & optimised therapy (POT) algorithm using five cognitive and behavioural skills for subthreshold depression

Abstract Personalising psychotherapies for depression may enhance their efficacy. We conducted a randomised controlled trial of smartphone cognitive-behavioural therapy (CBT) among 4,469 adults in Japan (RESiLIENT trial, UMIN-CTR UMIN000047124). Participants received one of nine CBT skills or combin...

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Main Authors: Toshi A. Furukawa, Hisashi Noma, Aran Tajika, Rie Toyomoto, Masatsugu Sakata, Yan Luo, Masaru Horikoshi, Tatsuo Akechi, Norito Kawakami, Takeo Nakayama, Naoki Kondo, Shingo Fukuma, James M. S. Wason, Ronald C. Kessler, Wolfgang Lutz, Pim Cuijpers
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-025-01906-6
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