Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation

Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation

Abstract Background Multiple Myeloma (MM) is the second most common hematological malignancy, characterized by the accumulation of monoclonal plasmocytes in the bone marrow. Despite advancements with proteasome inhibitors, immunomodulatory agents, and CD38-targeting antibodies, MM remains largely in...

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Main Authors: Jessy Sirera, Saharnaz Sarlak, Manon Teisseire, Alexandrine Carminati, Victoria J. Nicolini, Coline Savy, Patrick Brest, Thierry Juel, Christophe Bontoux, Marcel Deckert, Mickael Ohanna, Sandy Giuliano, Maeva Dufies, Gilles Pages, Frederic Luciano
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Multiple myeloma
Deubiquitinase
USP39
ZEB1
Migration
Online Access:https://doi.org/10.1186/s13046-024-03241-2
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https://doi.org/10.1186/s13046-024-03241-2

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