Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4–TAF6 axis in the cell cycle

Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4–TAF6 axis in the cell cycle

Abstract SETD1A is a member of the KMT2 histone H3K4 methyltransferase family of mammalian proteins. Aberrant SETD1A expression is associated with a poor prognosis in patients with gastric cancer (GC). We found that the catalytic domain of SETD1A is nonessential for GC cell proliferation, whereas th...

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Main Authors: Meng Ning, Takayuki Hoshii, Takuya Nakagawa, Genki Usui, Shintaro Izumi, Kanako Hayashi, Makoto Matsumoto, Bahityar Rahmutulla, Masaki Fukuyo, Hiroyuki Abe, Tetsuo Ushiku, Atsushi Kaneda
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07976-4
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https://doi.org/10.1038/s41419-025-07976-4

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