Comparative Analysis of 5-ALA and Fluorescent Techniques in High-Grade Glioma Treatment

Comparative Analysis of 5-ALA and Fluorescent Techniques in High-Grade Glioma Treatment

<b>Background:</b> 5-Aminolevulinic acid (5-ALA) serves as a precursor in the heme biosynthesis pathway, resulting in the selective accumulation of protoporphyrin IX (PpIX) within glioma cells. This property facilitates fluorescence-guided resection (FGR) in high-grade gliomas (HGGs), en...

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Main Authors: José E. Valerio, Guillermo de Jesús Aguirre Vera, Jorge Zumaeta, Noe Santiago Rea, Maria P. Fernandez Gomez, Penelope Mantilla-Farfan, Laurel Valente, Andrés M. Alvarez-Pinzon
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
5-aminolevulinic acid
high-grade glioma
sodium fluorescence
protoporphyrin
blood–brain barrier
Online Access:https://www.mdpi.com/2227-9059/13/5/1161
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