Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway

Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway

Abstract Objective Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by vascular remodeling and involves Endothelial-to-Mesenchymal transition (EndMT) in pulmonary artery endothelial cells (PAECs). EndMT is a complex cell differentiation process, mainly showing the de...

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Main Authors: Qiuhong Jiao, Xiufeng Xu, Longwu Xu, Yuying Wang, Shulan Pang, Jie Hao, Xiaohong Liu, Yudan Zhao, Wanpeng Qi, Limin Qin, Tao Huang, Jingtian Li, Tao Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
WGCNA
Pulmonary arterial hypertension
Pulmonary artery endothelial cells
TGFβ1/SMAD
Endothelial-to-mesenchymal transition
Online Access:https://doi.org/10.1186/s12967-025-06505-3
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https://doi.org/10.1186/s12967-025-06505-3

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