Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer

Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer

Abstract Immunotherapy has gained approval for use in small cell lung cancer (SCLC), yet only a subset of patients (10–20%) experience meaningful benefits, underscoring the urgent need for more effective therapeutic approaches. This work discovers a distinct HDAC7‐high SCLC phenotype characterized b...

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Main Authors: Tingting Qin, Jingya Wang, Jian Wang, Qingwu Du, Liuchun Wang, Hailin Liu, Wenting Liu, Xueyang Li, Yantao Jiang, Qi Xu, Junjie Yu, Huiyan Liu, Ting Wang, Mengjie Li, Dingzhi Huang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
c‐Myc
exportin (XPO) 1
histone deacetylase 7
selinexor
small cell lung cancer
Online Access:https://doi.org/10.1002/advs.202413445
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https://doi.org/10.1002/advs.202413445

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