Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis
Functional dyspepsia (FD) is a common chronic gastrointestinal disorder with a complex, undefined mechanism. Clustering of patients with FD in families highlights the role of genetic factors in the pathogenesis of FD. We performed a systematic review and meta-analysis to clarify the associations bet...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/3420548 |
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| author | Lijun Du John J. Kim Binrui Chen Yawen Zhang Hui Ren |
| author_facet | Lijun Du John J. Kim Binrui Chen Yawen Zhang Hui Ren |
| author_sort | Lijun Du |
| collection | DOAJ |
| description | Functional dyspepsia (FD) is a common chronic gastrointestinal disorder with a complex, undefined mechanism. Clustering of patients with FD in families highlights the role of genetic factors in the pathogenesis of FD. We performed a systematic review and meta-analysis to clarify the associations between specific gene polymorphisms and FD susceptibility. PubMed, EMBASE, the Cochrane Library, and HuGE database were searched. An additive model was adopted to determine whether previous studied genes are associated with FD susceptibility. Carriers of minor allele in GNB3 825C>T (OR=1.15, 95% CI 0.99-1.34, P=0.07), SCL6A4 5HTTLPR (OR=0.92, 95% CI 0.75-1.12, P=0.40), and CCK-1R 779T>C (OR=0.86, 95% CI 0.72-1.03, P=0.09) genes failed to demonstrate susceptibility to FD. In a subgroup analysis, only minor allele (T) in GNB3 825C>T was associated with an increased susceptibility to the epigastric pain syndrome subtype (OR=1.34, 95% CI 1.10-1.63, P=0.003). Our meta-analysis based on available studies using an additive model failed to show that GNB3, SCL6A4, and CCK-1R polymorphisms are associated with FD susceptibility. |
| format | Article |
| id | doaj-art-155527b3d2c34f0fb64d4af888e67fc9 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-155527b3d2c34f0fb64d4af888e67fc92025-02-03T06:12:35ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/34205483420548Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-AnalysisLijun Du0John J. Kim1Binrui Chen2Yawen Zhang3Hui Ren4Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDivision of Gastroenterology & Hepatology, Loma Linda University Health, Loma Linda, CA 92354, USADepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaFunctional dyspepsia (FD) is a common chronic gastrointestinal disorder with a complex, undefined mechanism. Clustering of patients with FD in families highlights the role of genetic factors in the pathogenesis of FD. We performed a systematic review and meta-analysis to clarify the associations between specific gene polymorphisms and FD susceptibility. PubMed, EMBASE, the Cochrane Library, and HuGE database were searched. An additive model was adopted to determine whether previous studied genes are associated with FD susceptibility. Carriers of minor allele in GNB3 825C>T (OR=1.15, 95% CI 0.99-1.34, P=0.07), SCL6A4 5HTTLPR (OR=0.92, 95% CI 0.75-1.12, P=0.40), and CCK-1R 779T>C (OR=0.86, 95% CI 0.72-1.03, P=0.09) genes failed to demonstrate susceptibility to FD. In a subgroup analysis, only minor allele (T) in GNB3 825C>T was associated with an increased susceptibility to the epigastric pain syndrome subtype (OR=1.34, 95% CI 1.10-1.63, P=0.003). Our meta-analysis based on available studies using an additive model failed to show that GNB3, SCL6A4, and CCK-1R polymorphisms are associated with FD susceptibility.http://dx.doi.org/10.1155/2019/3420548 |
| spellingShingle | Lijun Du John J. Kim Binrui Chen Yawen Zhang Hui Ren Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis |
| title_full | Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis |
| title_fullStr | Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis |
| title_short | Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis |
| title_sort | gene polymorphisms and susceptibility to functional dyspepsia a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2019/3420548 |
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