Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome
Background. Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS). Objective. To investigate the association between hyperuricemia and 1-year all-cause mortalit...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2020/2615147 |
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| _version_ | 1832546991874244608 |
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| author | Shi Tai Xuping Li Zhaowei Zhu Liang Tang Hui Yang Liyao Fu Xinqun Hu Zhenfei Fang Shenghua Zhou |
| author_facet | Shi Tai Xuping Li Zhaowei Zhu Liang Tang Hui Yang Liyao Fu Xinqun Hu Zhenfei Fang Shenghua Zhou |
| author_sort | Shi Tai |
| collection | DOAJ |
| description | Background. Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS). Objective. To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients with ACS. Methods. This retrospective cohort study included 711 consecutive ACS patients aged ≥75 years, hospitalized in our center between January 2013 and December 2017. Serum uric acid (sUA), in-hospital events, and 1-year follow-up were analyzed. Multivariable logistic regression models were used to explore the risk factors for in-hospital events and 1-year all-cause mortality. Results. sUA levels were higher in males than in females (381.4 ± 110.1 vs. 349.3 ± 119.1 μmol/l, P<0.001). Prevalence of hypertension (80.5% vs. 72.6%, P=0.020), atrial fibrillation (16.2% vs. 9.5%, P=0.008), and severe heart failure (61.0% vs. 44.2%, P<0.001) were higher in patients with hyperuricemia than in patients with normal sUA. During the 1-year follow-up, 135 patients died (19.0%); all-cause mortality was higher in patients with hyperuricemia than in patients with normal sUA (23.1% vs. 16.7%, P=0.039). Hyperuricemia is related to in-hospital ventricular tachycardia and 1-year all-cause mortality (OR = 1.799, 95% CI 1.050–3.081, P=0.033; OR = 1.512, 95% CI 1.028–2.225, P=0.036, respectively). Multivariable regression analysis models showed that hyperuricemia was an independent risk factor of 1-year all-cause mortality in women (OR = 2.539, 95% CI 1.001–6.453, P=0.050), but not in men (OR = 0.931, 95% CI 0.466–1.858, P=0.839) after adjustment for confounding variables. Conclusions. Hyperuricemia is an independent risk factor for 1-year all-cause mortality in elderly female patients with ACS. |
| format | Article |
| id | doaj-art-15423a288c3a4d9cba840d1ac69b9b12 |
| institution | Kabale University |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-15423a288c3a4d9cba840d1ac69b9b122025-02-03T06:46:23ZengWileyCardiovascular Therapeutics1755-59141755-59222020-01-01202010.1155/2020/26151472615147Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary SyndromeShi Tai0Xuping Li1Zhaowei Zhu2Liang Tang3Hui Yang4Liyao Fu5Xinqun Hu6Zhenfei Fang7Shenghua Zhou8Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaBackground. Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS). Objective. To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients with ACS. Methods. This retrospective cohort study included 711 consecutive ACS patients aged ≥75 years, hospitalized in our center between January 2013 and December 2017. Serum uric acid (sUA), in-hospital events, and 1-year follow-up were analyzed. Multivariable logistic regression models were used to explore the risk factors for in-hospital events and 1-year all-cause mortality. Results. sUA levels were higher in males than in females (381.4 ± 110.1 vs. 349.3 ± 119.1 μmol/l, P<0.001). Prevalence of hypertension (80.5% vs. 72.6%, P=0.020), atrial fibrillation (16.2% vs. 9.5%, P=0.008), and severe heart failure (61.0% vs. 44.2%, P<0.001) were higher in patients with hyperuricemia than in patients with normal sUA. During the 1-year follow-up, 135 patients died (19.0%); all-cause mortality was higher in patients with hyperuricemia than in patients with normal sUA (23.1% vs. 16.7%, P=0.039). Hyperuricemia is related to in-hospital ventricular tachycardia and 1-year all-cause mortality (OR = 1.799, 95% CI 1.050–3.081, P=0.033; OR = 1.512, 95% CI 1.028–2.225, P=0.036, respectively). Multivariable regression analysis models showed that hyperuricemia was an independent risk factor of 1-year all-cause mortality in women (OR = 2.539, 95% CI 1.001–6.453, P=0.050), but not in men (OR = 0.931, 95% CI 0.466–1.858, P=0.839) after adjustment for confounding variables. Conclusions. Hyperuricemia is an independent risk factor for 1-year all-cause mortality in elderly female patients with ACS.http://dx.doi.org/10.1155/2020/2615147 |
| spellingShingle | Shi Tai Xuping Li Zhaowei Zhu Liang Tang Hui Yang Liyao Fu Xinqun Hu Zhenfei Fang Shenghua Zhou Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome Cardiovascular Therapeutics |
| title | Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome |
| title_full | Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome |
| title_fullStr | Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome |
| title_full_unstemmed | Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome |
| title_short | Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome |
| title_sort | hyperuricemia is a risk factor for one year overall survival in elderly female patients with acute coronary syndrome |
| url | http://dx.doi.org/10.1155/2020/2615147 |
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