Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

IntroductionT Cell autoantibodies, TIgG and TIgM, as well as the T Cell-bound complement protein fragment C4d (TC4d) are novel diagnostic biomarkers that have demonstrated high specificity and sensitivity for SLE. The present study aims to characterize the clinical performance characteristics of the...

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Main Authors: Vasileios Kyttaris, Daniel J. Wallace, Arezou Khosroshahi, Andrew Concoff, Nicole Wilson, Chau Ching Liu, Susan Manzi, Joseph Ahearn, Sepehr Taghavi, Touba Warsi, Stanley Park, Christine Schleif, Brittany D. Partain, Tyler O’Malley
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
T cell biology
lymphocyte autoantibodies
complement activation in SLE
SLE biomarkers
diagnostic biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518208/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518208/full

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