SIRT7 facilitates endometrial cancer progression by regulating PTEN stability in an estrogen-dependent manner

SIRT7 facilitates endometrial cancer progression by regulating PTEN stability in an estrogen-dependent manner

Abstract The prognosis of metastatic endometrial carcinoma (EC), one of the most common gynecological malignancies worldwide, remains poor, and the underlying driver of metastases is poorly understood. Dysregulation in estrogen-related signaling and inactivation of tumor suppressor PTEN are two esse...

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Main Authors: Zhiyi Hu, Ming Tang, Yujia Huang, Bailian Cai, Xiaoxiang Sun, Guofang Chen, Ao Huang, Xiaoqi Li, Ab Rauf Shah, Lijun Jiang, Qian Li, Xianghong Xu, Wen Lu, Zhiyong Mao, Xiaoping Wan
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58317-0
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https://doi.org/10.1038/s41467-025-58317-0

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