Nuclear mechano-confinement induces geometry-dependent HP1α condensate alterations

Abstract Cells sense external physical cues through complex processes involving signaling pathways, cytoskeletal dynamics, and transcriptional regulation to coordinate a cellular response. A key emerging principle underlying such mechanoresponses is the interplay between nuclear morphology, chromati...

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Bibliographic Details
Main Authors: Oda Hovet, Negar Nahali, Andrea Halaburkova, Linda Hofstad Haugen, Jonas Paulsen, Cinzia Progida
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07732-6
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