Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy

Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy

Abstract Glioblastomas (GBM) are routinely treated with high doses of ionizing radiation (IR), yet these tumors recur quickly, and the recurrent tumors are highly therapy resistant. Here, we report that IR-induced senescence of tumor cells counterintuitively spurs GBM recurrence, driven by the senes...

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Main Authors: Nozomi Tomimatsu, Luis Fernando Macedo Di Cristofaro, Suman Kanji, Lorena Samentar, Benjamin Russell Jordan, Ralf Kittler, Amyn A Habib, Jair Machado Espindola-Netto, Tamara Tchkonia, James L Kirkland, Terry C Burns, Jann N Sarkaria, Andrea Gilbert, John R Floyd, Robert Hromas, Weixing Zhao, Daohong Zhou, Patrick Sung, Bipasha Mukherjee, Sandeep Burma
Format: Article
Language:English
Published: Springer Nature 2025-02-01
Series:EMBO Molecular Medicine
Subjects:
Glioblastoma Recurrence
Radiation Therapy
Therapy-induced Senescence
Senescence-associated Secretory Phenotype
Senolytic Therapy
Online Access:https://doi.org/10.1038/s44321-025-00201-x
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https://doi.org/10.1038/s44321-025-00201-x

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