The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes
Objective. We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). Methods. Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2931985 |
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| author | Gabriele Forlani Carlo Giorda Roberta Manti Natalia Mazzella Salvatore De Cosmo Maria Chiara Rossi Antonio Nicolucci Paolo Di Bartolo Antonio Ceriello Pietro Guida AMD-Annals Study Group |
| author_facet | Gabriele Forlani Carlo Giorda Roberta Manti Natalia Mazzella Salvatore De Cosmo Maria Chiara Rossi Antonio Nicolucci Paolo Di Bartolo Antonio Ceriello Pietro Guida AMD-Annals Study Group |
| author_sort | Gabriele Forlani |
| collection | DOAJ |
| description | Objective. We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). Methods. Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and centrally analyzed anonymously. After exclusion of 5967 cases (high or uncertain alcohol intake), in 38,880 the Fatty Liver Index (FLI) was used as a proxy for the diagnosis of NAFLD. Factors associated with FLI assessed NAFLD (FLI-NAFLD) were evaluated through multivariate analysis. Results. FLI-NAFLD was present in 59.6% of patients. Compared to non-NAFLD, FLI-NAFLD was associated with impairment in renal function, higher albumin excretion, HbA1c and blood pressure, lower HDL cholesterol, and poorer quality of care. ALT was within normal limits in 73.6% of FLI-NAFLD patients (45.6% if the updated reference values were used). The prevalence of FLI-NAFLD did not differ if the whole sample (94,577 cases) was examined, irrespective of alcohol intake. Conclusions. FLI-NAFLD was present in the majority of T2DM patients of our sample and metabolic derangement, not alcohol consumption, was mainly associated with the disease. FLI-NAFLD patients have a worse metabolic profile. ALT levels are not predictive of NAFLD. |
| format | Article |
| id | doaj-art-14c7612f3b7a44d4b8ed4c5ccd978543 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-14c7612f3b7a44d4b8ed4c5ccd9785432025-02-03T05:59:20ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/29319852931985The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 DiabetesGabriele Forlani0Carlo Giorda1Roberta Manti2Natalia Mazzella3Salvatore De Cosmo4Maria Chiara Rossi5Antonio Nicolucci6Paolo Di Bartolo7Antonio Ceriello8Pietro Guida9AMD-Annals Study Group10Unit of Metabolic Diseases and Clinical Dietetics, “Alma Mater Studiorum” University of Bologna, 40138 Bologna, ItalyDiabetes and Metabolism Unit, ASL Turin 5, 10023 Chieri, ItalyDiabetes and Metabolism Unit, ASL Turin 5, 10023 Chieri, ItalyUnit of Metabolic Diseases and Clinical Dietetics, “Alma Mater Studiorum” University of Bologna, 40138 Bologna, ItalyUnit of Internal Medicine, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyCenter for Outcomes Research and Clinical Epidemiology (CORE), 65124 Pescara, ItalyCenter for Outcomes Research and Clinical Epidemiology (CORE), 65124 Pescara, ItalyDiabetes Unit, AUSL Romagna, 48121 Ravenna, ItalyBiomedical Research Institute August Pi Sunyer (IDIBAPS) and Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), 08036 Barcelona, SpainAMD (Italian Association of Clinical Diabetologists), 00192 Rome, ItalyAMD (Italian Association of Clinical Diabetologists), 00192 Rome, ItalyObjective. We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). Methods. Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and centrally analyzed anonymously. After exclusion of 5967 cases (high or uncertain alcohol intake), in 38,880 the Fatty Liver Index (FLI) was used as a proxy for the diagnosis of NAFLD. Factors associated with FLI assessed NAFLD (FLI-NAFLD) were evaluated through multivariate analysis. Results. FLI-NAFLD was present in 59.6% of patients. Compared to non-NAFLD, FLI-NAFLD was associated with impairment in renal function, higher albumin excretion, HbA1c and blood pressure, lower HDL cholesterol, and poorer quality of care. ALT was within normal limits in 73.6% of FLI-NAFLD patients (45.6% if the updated reference values were used). The prevalence of FLI-NAFLD did not differ if the whole sample (94,577 cases) was examined, irrespective of alcohol intake. Conclusions. FLI-NAFLD was present in the majority of T2DM patients of our sample and metabolic derangement, not alcohol consumption, was mainly associated with the disease. FLI-NAFLD patients have a worse metabolic profile. ALT levels are not predictive of NAFLD.http://dx.doi.org/10.1155/2016/2931985 |
| spellingShingle | Gabriele Forlani Carlo Giorda Roberta Manti Natalia Mazzella Salvatore De Cosmo Maria Chiara Rossi Antonio Nicolucci Paolo Di Bartolo Antonio Ceriello Pietro Guida AMD-Annals Study Group The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes Journal of Diabetes Research |
| title | The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes |
| title_full | The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes |
| title_fullStr | The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes |
| title_full_unstemmed | The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes |
| title_short | The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes |
| title_sort | burden of nafld and its characteristics in a nationwide population with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2016/2931985 |
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