B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity

B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity

Summary: Immune-derived opioid peptides have been implicated in immune regulation and inflammatory processes. Here, we investigate the effects of nociceptin/orphanin FQ (N/OFQ) on metabolic function and inflammation in obesity. Selectively targeting N/OFQ, encoded by the Pnoc gene, in B cells mitiga...

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Bibliographic Details
Main Authors: Stephanie C. Puente-Ruiz, Leona Ide, Julia Schuller, Adel Ben-Kraiem, Anne Hoffmann, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Kerstin Krause, Martin Gericke, Nora Klöting, Jens C. Brüning, F. Thomas Wunderlich, Matthias Blüher, Alexander Jais
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Biological sciences
Endocrinology
Natural sciences
Physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225010806
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http://www.sciencedirect.com/science/article/pii/S2589004225010806

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