Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease
Introduction. Although 90% of prostate cancer is considered to be localized, 20%–30% of patients will experience biochemical failure (BF), defined as serum PSA >0.2 ng/mL, after radical prostatectomy (RP). The presence of circulating prostate cells (CPCs) in men without evidence of BF may be usef...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/762064 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561615631810560 |
|---|---|
| author | Nigel P. Murray Eduardo Reyes Nelson Orellana Cynthia Fuentealba Leonardo Bádinez Ruben Olivares José Porcell Ricardo Dueñas |
| author_facet | Nigel P. Murray Eduardo Reyes Nelson Orellana Cynthia Fuentealba Leonardo Bádinez Ruben Olivares José Porcell Ricardo Dueñas |
| author_sort | Nigel P. Murray |
| collection | DOAJ |
| description | Introduction. Although 90% of prostate cancer is considered to be localized, 20%–30% of patients will experience biochemical failure (BF), defined as serum PSA >0.2 ng/mL, after radical prostatectomy (RP). The presence of circulating prostate cells (CPCs) in men without evidence of BF may be useful to predict patients at risk for BF. We describe the frequency of CPCs detected after RP, relation with clinicopathological parameters, and association with biochemical failure. Methods and Patients. Serial blood samples were taken during followup after RP, mononuclear cells were obtained by differential gel centrifugation, and CPCs identified using standard immunocytochemistry using anti-PSA monoclonal antibodies. Age, pathological stage (organ confined, nonorgan confined), pathological grade, margin status (positive, negative), extracapsular extension, perineural, vascular, and lymphatic infiltration (positive, negative) were compared with the presence/absence of CPCs and with and without biochemical failure. Kaplan Meier methods were used to compare the unadjusted biochemical failure free survival of patients with and without CPCs. Results. 114 men participated, and secondary CPCs were detected more frequently in patients with positive margins, extracapsular extension, and vascular and lymphatic infiltration and were associated with biochemical failure independent of these clinicopathological variables, and with a shorter time to BF. Conclusions. Secondary CPCs are an independent risk factor associated with increased BF in men with a PSA <0.2 ng/mL after radical prostatectomy, but do not determine if the recurrence is due to local or systemic disease. These results warrant larger studies to confirm the findings. |
| format | Article |
| id | doaj-art-145a93b0d6334a8e9f6f6e2d7a84cefb |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-145a93b0d6334a8e9f6f6e2d7a84cefb2025-02-03T01:24:32ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/762064762064Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of DiseaseNigel P. Murray0Eduardo Reyes1Nelson Orellana2Cynthia Fuentealba3Leonardo Bádinez4Ruben Olivares5José Porcell6Ricardo Dueñas7Division of Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa, 7770199 Santiago, ChileFaculty of Medicine, Universidad Diego Portales, Manuel Rodriguez Sur 415, 8370179 Santiago, ChileUrology Division, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa, 7770199 Santiago, ChileUrology Division, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa, 7770199 Santiago, ChileFoundation Arturo Lopez Perez, Rancagua 899, Providencia, 7500921 Santiago, ChileUrology Division, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa, 7770199 Santiago, ChileDivision of Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa, 7770199 Santiago, ChileUrology Division, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa, 7770199 Santiago, ChileIntroduction. Although 90% of prostate cancer is considered to be localized, 20%–30% of patients will experience biochemical failure (BF), defined as serum PSA >0.2 ng/mL, after radical prostatectomy (RP). The presence of circulating prostate cells (CPCs) in men without evidence of BF may be useful to predict patients at risk for BF. We describe the frequency of CPCs detected after RP, relation with clinicopathological parameters, and association with biochemical failure. Methods and Patients. Serial blood samples were taken during followup after RP, mononuclear cells were obtained by differential gel centrifugation, and CPCs identified using standard immunocytochemistry using anti-PSA monoclonal antibodies. Age, pathological stage (organ confined, nonorgan confined), pathological grade, margin status (positive, negative), extracapsular extension, perineural, vascular, and lymphatic infiltration (positive, negative) were compared with the presence/absence of CPCs and with and without biochemical failure. Kaplan Meier methods were used to compare the unadjusted biochemical failure free survival of patients with and without CPCs. Results. 114 men participated, and secondary CPCs were detected more frequently in patients with positive margins, extracapsular extension, and vascular and lymphatic infiltration and were associated with biochemical failure independent of these clinicopathological variables, and with a shorter time to BF. Conclusions. Secondary CPCs are an independent risk factor associated with increased BF in men with a PSA <0.2 ng/mL after radical prostatectomy, but do not determine if the recurrence is due to local or systemic disease. These results warrant larger studies to confirm the findings.http://dx.doi.org/10.1155/2013/762064 |
| spellingShingle | Nigel P. Murray Eduardo Reyes Nelson Orellana Cynthia Fuentealba Leonardo Bádinez Ruben Olivares José Porcell Ricardo Dueñas Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease The Scientific World Journal |
| title | Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease |
| title_full | Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease |
| title_fullStr | Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease |
| title_full_unstemmed | Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease |
| title_short | Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease |
| title_sort | secondary circulating prostate cells predict biochemical failure in prostate cancer patients after radical prostatectomy and without evidence of disease |
| url | http://dx.doi.org/10.1155/2013/762064 |
| work_keys_str_mv | AT nigelpmurray secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease AT eduardoreyes secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease AT nelsonorellana secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease AT cynthiafuentealba secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease AT leonardobadinez secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease AT rubenolivares secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease AT joseporcell secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease AT ricardoduenas secondarycirculatingprostatecellspredictbiochemicalfailureinprostatecancerpatientsafterradicalprostatectomyandwithoutevidenceofdisease |