Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary Syndromes
Background. Recent intravascular ultrasound (IVUS) studies have demonstrated that hypoechoic plaque with deep ultrasound attenuation despite absence of bright calcium is common in acute coronary syndrome. Such “attenuated plaque” may be an IVUS characteristic of unstable lesion. Methods. We used op...
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| Format: | Article |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/687515 |
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| author | Takashi Kubo Yoshiki Matsuo Yasushi Ino Takashi Tanimoto Kohei Ishibashi Kenichi Komukai Hironori Kitabata Atsushi Tanaka Keizo Kimura Toshio Imanishi Takashi Akasaka |
| author_facet | Takashi Kubo Yoshiki Matsuo Yasushi Ino Takashi Tanimoto Kohei Ishibashi Kenichi Komukai Hironori Kitabata Atsushi Tanaka Keizo Kimura Toshio Imanishi Takashi Akasaka |
| author_sort | Takashi Kubo |
| collection | DOAJ |
| description | Background. Recent intravascular ultrasound (IVUS) studies have demonstrated that hypoechoic plaque with deep ultrasound attenuation despite absence of bright calcium is common in acute coronary syndrome. Such “attenuated plaque” may be an IVUS characteristic of unstable lesion.
Methods. We used optical coherence tomography (OCT) in 104 patients with unstable angina to compare lesion characteristics between IVUS-detected attenuated plaque and nonattenuated plaque.
Results. IVUS-detected attenuated plaque was observed in 41 (39%) patients. OCT-detected lipidic plaque (88% versus 49%, 𝑃<0.001), thin-cap fibroatheroma (48% versus 16%, 𝑃<0.001), plaque rupture (44% versus 11%, 𝑃<0.001), and intracoronary thrombus (54% versus 17%, 𝑃<0.001) were more often seen in IVUS-detected attenuated plaques compared with nonattenuated plaques.
Conclusions. IVUS-detected attenuated plaque has many characteristics of unstable coronary lesion. The presence of attended plaque might be an important marker of lesion instability. |
| format | Article |
| id | doaj-art-1459eee20afa4a4fbfaf8c69647b030a |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-1459eee20afa4a4fbfaf8c69647b030a2025-02-03T01:02:59ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/687515687515Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary SyndromesTakashi Kubo0Yoshiki Matsuo1Yasushi Ino2Takashi Tanimoto3Kohei Ishibashi4Kenichi Komukai5Hironori Kitabata6Atsushi Tanaka7Keizo Kimura8Toshio Imanishi9Takashi Akasaka10Department of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanDepartment of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, JapanBackground. Recent intravascular ultrasound (IVUS) studies have demonstrated that hypoechoic plaque with deep ultrasound attenuation despite absence of bright calcium is common in acute coronary syndrome. Such “attenuated plaque” may be an IVUS characteristic of unstable lesion. Methods. We used optical coherence tomography (OCT) in 104 patients with unstable angina to compare lesion characteristics between IVUS-detected attenuated plaque and nonattenuated plaque. Results. IVUS-detected attenuated plaque was observed in 41 (39%) patients. OCT-detected lipidic plaque (88% versus 49%, 𝑃<0.001), thin-cap fibroatheroma (48% versus 16%, 𝑃<0.001), plaque rupture (44% versus 11%, 𝑃<0.001), and intracoronary thrombus (54% versus 17%, 𝑃<0.001) were more often seen in IVUS-detected attenuated plaques compared with nonattenuated plaques. Conclusions. IVUS-detected attenuated plaque has many characteristics of unstable coronary lesion. The presence of attended plaque might be an important marker of lesion instability.http://dx.doi.org/10.4061/2011/687515 |
| spellingShingle | Takashi Kubo Yoshiki Matsuo Yasushi Ino Takashi Tanimoto Kohei Ishibashi Kenichi Komukai Hironori Kitabata Atsushi Tanaka Keizo Kimura Toshio Imanishi Takashi Akasaka Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary Syndromes Cardiology Research and Practice |
| title | Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary Syndromes |
| title_full | Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary Syndromes |
| title_fullStr | Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary Syndromes |
| title_full_unstemmed | Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary Syndromes |
| title_short | Optical Coherence Tomography Analysis of Attenuated Plaques Detected by Intravascular Ultrasound in Patients with Acute Coronary Syndromes |
| title_sort | optical coherence tomography analysis of attenuated plaques detected by intravascular ultrasound in patients with acute coronary syndromes |
| url | http://dx.doi.org/10.4061/2011/687515 |
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