The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts
Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/434127 |
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| author | Rafaela Torres Portugal Leite Sarah de Oliveira Nogueira João Paulo Rodrigues do Nascimento Laisa Soares de Lima Taís Bastos da Nóbrega Mariana da Silva Virgínio Lucas Monte da Costa Moreno Bruno Henrique Barbosa Sampaio Fábio Gomes de Matos e Souza |
| author_facet | Rafaela Torres Portugal Leite Sarah de Oliveira Nogueira João Paulo Rodrigues do Nascimento Laisa Soares de Lima Taís Bastos da Nóbrega Mariana da Silva Virgínio Lucas Monte da Costa Moreno Bruno Henrique Barbosa Sampaio Fábio Gomes de Matos e Souza |
| author_sort | Rafaela Torres Portugal Leite |
| collection | DOAJ |
| description | Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early onset of BD and for suicide attempts. Materials and Methods. PubMed database was searched for articles using key words “bipolar disorder,” “suicide attempts,” “cannabis,” “marijuana,” “early age at onset,” and “early onset.” Results. The following percentages in bipolar patients were found: suicide attempts 3.6–42%; suicide attempts and substance use 5–60%; suicide attempts and cannabis use 15–42%. An early AAO was associated with cannabis misuse. The mean age of the first manic episode in individuals with and without BD and cannabis use disorder (CUD) was 19.5 and 25.1 years, respectively. The first depressive episode was at 18.5 and 24.4 years, respectively. Individuals misusing cannabis showed increased risk of suicide. Discussion. Cannabis use is associated with increased risk of suicide attempts and with early AAO. However, the effect of cannabis at the AAO and suicide attempts is not clear. |
| format | Article |
| id | doaj-art-14379db8b1db4e1fa347b238cfa76f0c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-14379db8b1db4e1fa347b238cfa76f0c2025-02-03T06:01:09ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/434127434127The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide AttemptsRafaela Torres Portugal Leite0Sarah de Oliveira Nogueira1João Paulo Rodrigues do Nascimento2Laisa Soares de Lima3Taís Bastos da Nóbrega4Mariana da Silva Virgínio5Lucas Monte da Costa Moreno6Bruno Henrique Barbosa Sampaio7Fábio Gomes de Matos e Souza8Faculty of Medicine, University of Fortaleza, 221 Desembargador Floriano Benevides Street, 60811-905 Fortaleza, CE, BrazilDepartment of Psychology, Federal University of Ceará, 2762 Universidade Avenida, 60020-181 Fortaleza, CE, BrazilFaculty of Medicine, Christus University Center, 133 João Adolfo Gurgel Street, Fortaleza, CE, BrazilDepartment of Psychology, Federal University of Ceará, 2762 Universidade Avenida, 60020-181 Fortaleza, CE, BrazilDepartment of Psychology, Federal University of Ceará, 2762 Universidade Avenida, 60020-181 Fortaleza, CE, BrazilDepartment of Psychology, Federal University of Ceará, 2762 Universidade Avenida, 60020-181 Fortaleza, CE, BrazilFaculty of Medicine, Federal University of Ceará, 949 Alexandre Baraúna Street, 60430-160 Fortaleza, CE, BrazilDepartment of Psychology, Federal University of Ceará, 2762 Universidade Avenida, 60020-181 Fortaleza, CE, BrazilDepartment of Clinical Medicine, Federal University of Ceará, 1290 Capitão Francisco Pedro Street, 60430-140 Fortaleza, CE, BrazilIntroduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early onset of BD and for suicide attempts. Materials and Methods. PubMed database was searched for articles using key words “bipolar disorder,” “suicide attempts,” “cannabis,” “marijuana,” “early age at onset,” and “early onset.” Results. The following percentages in bipolar patients were found: suicide attempts 3.6–42%; suicide attempts and substance use 5–60%; suicide attempts and cannabis use 15–42%. An early AAO was associated with cannabis misuse. The mean age of the first manic episode in individuals with and without BD and cannabis use disorder (CUD) was 19.5 and 25.1 years, respectively. The first depressive episode was at 18.5 and 24.4 years, respectively. Individuals misusing cannabis showed increased risk of suicide. Discussion. Cannabis use is associated with increased risk of suicide attempts and with early AAO. However, the effect of cannabis at the AAO and suicide attempts is not clear.http://dx.doi.org/10.1155/2015/434127 |
| spellingShingle | Rafaela Torres Portugal Leite Sarah de Oliveira Nogueira João Paulo Rodrigues do Nascimento Laisa Soares de Lima Taís Bastos da Nóbrega Mariana da Silva Virgínio Lucas Monte da Costa Moreno Bruno Henrique Barbosa Sampaio Fábio Gomes de Matos e Souza The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts Neural Plasticity |
| title | The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts |
| title_full | The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts |
| title_fullStr | The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts |
| title_full_unstemmed | The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts |
| title_short | The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts |
| title_sort | use of cannabis as a predictor of early onset of bipolar disorder and suicide attempts |
| url | http://dx.doi.org/10.1155/2015/434127 |
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