A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of <i>Nrf2</i> Augments the Cytotoxic Effect Evoked by Tyrosinase in Melanogenic Cells

A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of <i>Nrf2</i> Augments the Cytotoxic Effect Evoked by Tyrosinase in Melanogenic Cells

Chemical leukoderma is a disorder induced by chemicals such as rhododendrol and monobenzone. These compounds possess a <i>p</i>-substituted phenol moiety and undergo oxidation into highly reactive and toxic <i>o</i>-quinone metabolites by tyrosinase. This metabolic activation...

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Bibliographic Details
Main Authors: Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
chemical leukoderma
<i>o</i>-quinone
tyrosinase
Nrf2
Slc7a11
Nqo1
Online Access:https://www.mdpi.com/2218-273X/15/1/114
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