Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro

Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro

To elucidate and to inhibit post-surgical fibrotic processes after trabeculectomy in glaucoma therapy, we measured gene expression in a fibrotic cell culture model, based on transforming growth factor TGF-β induction in primary human tenon fibroblasts (hTFs), and used Connectivity Map (CMap) data fo...

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Main Authors: Thomas Stahnke, Beata Gajda-Deryło, Anselm G. Jünemann, Oliver Stachs, Katharina A. Sterenczak, Robert Rejdak, Julia Beck, Ekkehard Schütz, Steffen Möller, Israel Barrantes, Gregor Warsow, Stephan Struckmann, Georg Fuellen
Format: Article
Language:English
Published: The Royal Society 2020-09-01
Series:Royal Society Open Science
Subjects:
fibrosis
drug repositioning
glaucoma surgery
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.200441
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https://royalsocietypublishing.org/doi/10.1098/rsos.200441

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