Cytokine landscapes of pregnancy: mapping gestational immune phases
Background Synchronised physiological adaptations occur during pregnancy to achieve systemic, immune and neuroendocrine equilibrium in the mother’s body, allowing semiallogenic fetal growth.Main text Depending on the cytokine profile alterations occurring through pregnancy, the latter can be divided...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-04-01
|
| Series: | Gynecology and Obstetrics Clinical Medicine |
| Online Access: | https://gocm.bmj.com/content/4/1/e000011.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595376122626048 |
|---|---|
| author | Sulagna Dutta Pallav Sengupta Fong Fong Liew |
| author_facet | Sulagna Dutta Pallav Sengupta Fong Fong Liew |
| author_sort | Sulagna Dutta |
| collection | DOAJ |
| description | Background Synchronised physiological adaptations occur during pregnancy to achieve systemic, immune and neuroendocrine equilibrium in the mother’s body, allowing semiallogenic fetal growth.Main text Depending on the cytokine profile alterations occurring through pregnancy, the latter can be divided into three distinct phases. In the first immunological phase of pregnancy, proinflammatory cytokines promote inflammatory reactions needed for implantation. In the second phase, a possible change from proinflammatory to anti-inflammatory cytokines creates a symbiosis between maternal and fetal components, ensuring fetal development. In the third phase, inflammatory and cytolytic cytokines operate again to reinforce an inflammatory environment for parturition. The article offers a detailed account of immune adaptations during pregnancy and highlights the distinctive cytokine profiles that mark each phase.Conclusion By providing a simplified depiction of pregnancy phases based on cytokine profiles, the article aims to inspire more research in reproductive immunology and improve the management of pregnancy-related inflammation and infection. |
| format | Article |
| id | doaj-art-13d4a0ebe97744d8a299720bfb5c7564 |
| institution | Kabale University |
| issn | 2097-0587 2667-1646 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Gynecology and Obstetrics Clinical Medicine |
| spelling | doaj-art-13d4a0ebe97744d8a299720bfb5c75642025-01-19T06:10:10ZengBMJ Publishing GroupGynecology and Obstetrics Clinical Medicine2097-05872667-16462024-04-014110.1136/gocm-2024-000011Cytokine landscapes of pregnancy: mapping gestational immune phasesSulagna Dutta0Pallav Sengupta1Fong Fong Liew2School of Medical Sciences, Bharath Institute of Higher Education and Research (BIHER), Tamil Nadu, IndiaDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates3 Department of Preclinical Sciences, Faculty of Dentistry, MAHSA University, Kuala Lumpur, MalaysiaBackground Synchronised physiological adaptations occur during pregnancy to achieve systemic, immune and neuroendocrine equilibrium in the mother’s body, allowing semiallogenic fetal growth.Main text Depending on the cytokine profile alterations occurring through pregnancy, the latter can be divided into three distinct phases. In the first immunological phase of pregnancy, proinflammatory cytokines promote inflammatory reactions needed for implantation. In the second phase, a possible change from proinflammatory to anti-inflammatory cytokines creates a symbiosis between maternal and fetal components, ensuring fetal development. In the third phase, inflammatory and cytolytic cytokines operate again to reinforce an inflammatory environment for parturition. The article offers a detailed account of immune adaptations during pregnancy and highlights the distinctive cytokine profiles that mark each phase.Conclusion By providing a simplified depiction of pregnancy phases based on cytokine profiles, the article aims to inspire more research in reproductive immunology and improve the management of pregnancy-related inflammation and infection.https://gocm.bmj.com/content/4/1/e000011.full |
| spellingShingle | Sulagna Dutta Pallav Sengupta Fong Fong Liew Cytokine landscapes of pregnancy: mapping gestational immune phases Gynecology and Obstetrics Clinical Medicine |
| title | Cytokine landscapes of pregnancy: mapping gestational immune phases |
| title_full | Cytokine landscapes of pregnancy: mapping gestational immune phases |
| title_fullStr | Cytokine landscapes of pregnancy: mapping gestational immune phases |
| title_full_unstemmed | Cytokine landscapes of pregnancy: mapping gestational immune phases |
| title_short | Cytokine landscapes of pregnancy: mapping gestational immune phases |
| title_sort | cytokine landscapes of pregnancy mapping gestational immune phases |
| url | https://gocm.bmj.com/content/4/1/e000011.full |
| work_keys_str_mv | AT sulagnadutta cytokinelandscapesofpregnancymappinggestationalimmunephases AT pallavsengupta cytokinelandscapesofpregnancymappinggestationalimmunephases AT fongfongliew cytokinelandscapesofpregnancymappinggestationalimmunephases |