Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction

Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction

Abstract Tumor tissues obtained in the clinical setting typically have low purity and display treatment-associated genetic heterogeneity, contributing to variants at low variant allele fractions (VAF). We present a pan-cancer landscape and the therapeutic impact of somatic variants detected at low V...

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Main Authors: Saumya D. Sisoudiya, Hanna Tukachinsky, Rachel B. Keller-Evans, Alexa B. Schrock, Richard S. P. Huang, Ole Gjoerup, Michael J. Pishvaian, Rachna Shroff, Ethan S. Sokol, Lucas Dennis, Garrett M. Frampton, Smruthy Sivakumar
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00991-w
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https://doi.org/10.1038/s41698-025-00991-w

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