The superoxide dismutase mimetic TEMPOL modulates nicotine-induced hyperlocomotor activity and nicotine-taking behavior in male rats

The superoxide dismutase mimetic TEMPOL modulates nicotine-induced hyperlocomotor activity and nicotine-taking behavior in male rats

Abstract Reactive oxygen species (ROS) have been implicated in behaviors induced by acute or repeated cocaine or methamphetamine administration in rodents. In the present study, we investigated the involvement of ROS in behavioral changes induced by nicotine administration and dopamine (DA) transmis...

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Bibliographic Details
Main Authors: Kyung Oh Jeon, Jordan T. Yorgason, Lauren Ford, Joel T. Woolley, Seong-Hoon Park, Byoung-Seok Lee, Eun Kyeong Lee, Jaerang Rho, Eun Young Jang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Dopamine
Hyperlocomotor
Nicotine
Nucleus accumbens
Oxidative stress
ROS
Online Access:https://doi.org/10.1038/s41598-025-88667-0
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https://doi.org/10.1038/s41598-025-88667-0

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