Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders

Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders

Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals. Here we report the discovery and characterization of first-in-class, humanized PRL neutralizing monoclonal antibodies (PRL mAbs). We obtained two pot...

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Bibliographic Details
Main Authors: Stephanie Maciuba, Gregory D. Bowden, Harrison J. Stratton, Kazimierz Wisniewski, Claudio D. Schteingart, Juan C. Almagro, Philippe Valadon, Joshua Lowitz, Scott M. Glaser, Grace Lee, Mahdi Dolatyari, Edita Navratilova, Frank Porreca, Pierre J.M. Rivière
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Antibody
prolactin
pain
sex-selective
women
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2254676
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https://www.tandfonline.com/doi/10.1080/19420862.2023.2254676

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