Synthesis of 5-Fluorouracil (5-FU) coated platinum nanoparticles and apoptotic effects on U87 human glioblastoma cells

Synthesis of 5-Fluorouracil (5-FU) coated platinum nanoparticles and apoptotic effects on U87 human glioblastoma cells

Abstract Background 5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent; however, its clinical application is often limited by systemic toxicity and the development of drug resistance. To enhance its therapeutic efficacy, novel drug delivery strategies are under investigation. This study e...

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Bibliographic Details
Main Authors: Atena Abed, Merat Karimi, Majid Nejati, Michael R. Hamblin, Seyed Abbas Mirzaei, Mostafa Sarvizadeh, Hamed Mirzaei
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
5-Fluorouracil (5-FU)
Platinum nanoparticles (PtNPs)
Glioblastoma
Apoptosis
Drug delivery
Molecular docking
Online Access:https://doi.org/10.1186/s12935-025-03893-w
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https://doi.org/10.1186/s12935-025-03893-w

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