High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period
This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake i...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2009/768398 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558776595513344 |
|---|---|
| author | W. Louis Cleveland Robert L. DeLaPaz Rashid A. Fawwaz Roger S. Challop |
| author_facet | W. Louis Cleveland Robert L. DeLaPaz Rashid A. Fawwaz Roger S. Challop |
| author_sort | W. Louis Cleveland |
| collection | DOAJ |
| description | This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group A 𝛽-hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR). Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation. Education and social life were resumed and evidence suggests improved cognition. Our findings motivate further study of glycine treatment of OCD and BDD. |
| format | Article |
| id | doaj-art-1344e519b83843a7bba3274d9a8c5bd2 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-1344e519b83843a7bba3274d9a8c5bd22025-02-03T01:31:28ZengWileyNeural Plasticity2090-59041687-54432009-01-01200910.1155/2009/768398768398High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year PeriodW. Louis Cleveland0Robert L. DeLaPaz1Rashid A. Fawwaz2Roger S. Challop3Department of Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY 10019, USADepartment of Radiology, New York-Presbyterian Hospital, Columbia-Presbyterian Medical Center, New York, NY 10032, USADepartment of Radiology, New York-Presbyterian Hospital, Columbia-Presbyterian Medical Center, New York, NY 10032, USADepartment of Pediatrics, New York-Presbyterian Hospital, Columbia-Presbyterian Medical Center, New York, NY 10032, USAThis paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group A 𝛽-hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR). Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation. Education and social life were resumed and evidence suggests improved cognition. Our findings motivate further study of glycine treatment of OCD and BDD.http://dx.doi.org/10.1155/2009/768398 |
| spellingShingle | W. Louis Cleveland Robert L. DeLaPaz Rashid A. Fawwaz Roger S. Challop High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period Neural Plasticity |
| title | High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period |
| title_full | High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period |
| title_fullStr | High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period |
| title_full_unstemmed | High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period |
| title_short | High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period |
| title_sort | high dose glycine treatment of refractory obsessive compulsive disorder and body dysmorphic disorder in a 5 year period |
| url | http://dx.doi.org/10.1155/2009/768398 |
| work_keys_str_mv | AT wlouiscleveland highdoseglycinetreatmentofrefractoryobsessivecompulsivedisorderandbodydysmorphicdisorderina5yearperiod AT robertldelapaz highdoseglycinetreatmentofrefractoryobsessivecompulsivedisorderandbodydysmorphicdisorderina5yearperiod AT rashidafawwaz highdoseglycinetreatmentofrefractoryobsessivecompulsivedisorderandbodydysmorphicdisorderina5yearperiod AT rogerschallop highdoseglycinetreatmentofrefractoryobsessivecompulsivedisorderandbodydysmorphicdisorderina5yearperiod |