Identification of Two Flavonoids as New and Safe Inhibitors of Kynurenine Aminotransferase II via Computational and In Vitro Study

Identification of Two Flavonoids as New and Safe Inhibitors of Kynurenine Aminotransferase II via Computational and In Vitro Study

<b>Background/Objectives:</b> Kynurenine aminotransferase II (KAT-II) is a target for treating several diseases characterized by an excess of kynurenic acid (KYNA). Although KAT-II inactivators are available, they often lead to adverse side effects due to their irreversible inhibition me...

Full description

Saved in:
Bibliographic Details
Main Authors: Redouane Rebai, Luc Jasmin, Abdennacer Boudah
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceuticals
Subjects:
herbacetin
(-)-Epicatechin
KAT-II inhibition
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/1424-8247/18/1/76
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1424-8247/18/1/76

Similar Items