IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex

IL-7 signaling via IL-7Rα and common γ-chain (γc) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-...

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Main Authors: Tae Sik Goh, Yuna Jo, Byunghyuk Lee, Geona Kim, Hyunju Hwang, Eunhee Ko, Seung Wan Kang, Sae-Ock Oh, Sun-Yong Baek, Sik Yoon, Jung Sub Lee, Changwan Hong
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2017/9096829
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