Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells

Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells

Abstract Hematopoietic stem and progenitor cells (HSPCs) are critical for the treatment of blood diseases in clinic. However, the limited source of HSPCs severely hinders their clinical application. In the embryo, hematopoietic stem cells (HSCs) arise from hemogenic endothelial (HE) cells lining the...

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Bibliographic Details
Main Authors: Guixian Liang, Shicheng Liu, Chunyu Zhou, Mengyao Liu, Yifan Zhang, Dongyuan Ma, Lu Wang, Jing-Dong J. Han, Feng Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00760-2
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