PPARs Mediate Lipid Signaling in Inflammation and Cancer
Lipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator-activated receptors (PPARs). PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/134059 |
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| _version_ | 1832551928728387584 |
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| author | Liliane Michalik Walter Wahli |
| author_facet | Liliane Michalik Walter Wahli |
| author_sort | Liliane Michalik |
| collection | DOAJ |
| description | Lipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator-activated receptors (PPARs). PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. Epidemiological studies have established that tumor progression may be exacerbated by chronic inflammation. Here, we describe the production of the lipids that act as activators of PPARs, and we review the roles of these receptors in inflammation and cancer. Finally, we consider emerging strategies for therapeutic intervention. |
| format | Article |
| id | doaj-art-12cd5ddb2bd04c0e98a3454d24eca31f |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-12cd5ddb2bd04c0e98a3454d24eca31f2025-02-03T06:00:04ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/134059134059PPARs Mediate Lipid Signaling in Inflammation and CancerLiliane Michalik0Walter Wahli1Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, 1015 Lausanne, SwitzerlandCenter for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, 1015 Lausanne, SwitzerlandLipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator-activated receptors (PPARs). PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. Epidemiological studies have established that tumor progression may be exacerbated by chronic inflammation. Here, we describe the production of the lipids that act as activators of PPARs, and we review the roles of these receptors in inflammation and cancer. Finally, we consider emerging strategies for therapeutic intervention.http://dx.doi.org/10.1155/2008/134059 |
| spellingShingle | Liliane Michalik Walter Wahli PPARs Mediate Lipid Signaling in Inflammation and Cancer PPAR Research |
| title | PPARs Mediate Lipid Signaling in Inflammation and Cancer |
| title_full | PPARs Mediate Lipid Signaling in Inflammation and Cancer |
| title_fullStr | PPARs Mediate Lipid Signaling in Inflammation and Cancer |
| title_full_unstemmed | PPARs Mediate Lipid Signaling in Inflammation and Cancer |
| title_short | PPARs Mediate Lipid Signaling in Inflammation and Cancer |
| title_sort | ppars mediate lipid signaling in inflammation and cancer |
| url | http://dx.doi.org/10.1155/2008/134059 |
| work_keys_str_mv | AT lilianemichalik pparsmediatelipidsignalingininflammationandcancer AT walterwahli pparsmediatelipidsignalingininflammationandcancer |