Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells

Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells

Abstract This study investigates the role of Cathepsin D (CTSD) in diabetic vascular complications, particularly its impact on the phenotypic transformation of vascular smooth muscle cells (VSMCs) induced by advanced glycation end-products (AGEs), and explores its potential molecular mechanisms. CTS...

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Bibliographic Details
Main Authors: Xingmin He, Songhao Tian, Lixia Bu, Xinna Zhao, Liqiang Zheng, Peigang Zhang, Renwei Guo, Mingfeng Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Cathepsin D (CTSD)
Advanced glycation end-products (AGEs)
Vascular smooth muscle cells (VSMCs)
Phenotypic transformation
Transcriptomics and metabolomics analysis
Online Access:https://doi.org/10.1038/s41598-025-96038-y
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https://doi.org/10.1038/s41598-025-96038-y

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