Different responses involving Tfh cells delay parasite-specific antibody production in Trypanosoma cruzi acute experimental models

Different responses involving Tfh cells delay parasite-specific antibody production in Trypanosoma cruzi acute experimental models

IntroductionChagas disease (CD), caused by the parasite Trypanosoma cruzi, affects millions globally. Despite treatment options in the acute phase, most infections progress to a chronic indeterminate form or develop severe cardiac/gastrointestinal complications. Understanding the immune response is...

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Bibliographic Details
Main Authors: Ana Carolina Leão, Maria Jose Villar, Rakesh Adhikari, Cristina Poveda, Leroy Versteeg, Gregório Almeida, Peter J. Hotez, Maria Elena Bottazzi, Kathryn M. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
Chagas disease
Tfh
Th1
B cells
antibody
T. cruzi
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487317/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487317/full

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