Pygo2+ T cells possess immunosuppressive features and inferior immunotherapeutic response in gastric cancer

Pygo2+ T cells possess immunosuppressive features and inferior immunotherapeutic response in gastric cancer

BackgroundGastric cancer (GC) poses a significant threat to human health. Despite considerable advancements in immunotherapy for GC, the effectiveness of current immunotherapeutic targets remains constrained by the heterogeneity of the tumor microenvironment and mechanisms of immune evasion. Consequ...

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Bibliographic Details
Main Authors: Weilong Chang, Huifang Yan, Yawei Zhang, Zibo Sang, Bei Bu, Rui Deng, Kaibo Li, Jiajing Li, Yang Fu, Jinyuan Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
immunotherapeutic response
Pygo2
single-cell sequencing
immune microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596434/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596434/full

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