Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa
Limited data exist on HIV-1 drug resistance patterns in South Africa following second-line protease-inhibitor containing regimen failure. This study examined drug resistance patterns emerging in 75 HIV-1 infected adults experiencing virologic failure on a second-line regimen containing 2 NRTI and lo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2011/769627 |
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| _version_ | 1832546110711791616 |
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| author | Carole L. Wallis John W. Mellors Willem D. F. Venter Ian Sanne Wendy Stevens |
| author_facet | Carole L. Wallis John W. Mellors Willem D. F. Venter Ian Sanne Wendy Stevens |
| author_sort | Carole L. Wallis |
| collection | DOAJ |
| description | Limited data exist on HIV-1 drug resistance patterns in South Africa following second-line protease-inhibitor containing regimen failure. This study examined drug resistance patterns emerging in 75 HIV-1 infected adults experiencing virologic failure on a second-line regimen containing 2 NRTI and lopinavir/ritonavir. Ninety six percent of patients (n=72) were infected with HIV-1 subtype C, two patients were infected with HIV-1 subtype D and one with HIV-1 subtype A1. Thirty nine percent (n=29) of patients had no resistance mutations in protease or reverse transcriptase suggesting that medication non-adherence was a major factor contributing to failure. Major lopinavir resistance mutations were infrequent (5 of 75; 7%), indicating that drug resistance is not the main barrier to future viral suppression. |
| format | Article |
| id | doaj-art-127fd6fcbdd34e7bbdcb70894d4b2f7f |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-127fd6fcbdd34e7bbdcb70894d4b2f7f2025-02-03T07:23:49ZengWileyAIDS Research and Treatment2090-12402090-12592011-01-01201110.1155/2011/769627769627Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South AfricaCarole L. Wallis0John W. Mellors1Willem D. F. Venter2Ian Sanne3Wendy Stevens4Department of Molecular Medicine & Hematology , University of the Witwatersrand, Wits Medical School, 3B22, 3rd Floor, 7 York Road, Parktown 2193, South AfricaDivision of Infectious Diseases, University of Pittsburgh, Pittsburgh, USA Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, South AfricaClinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Molecular Medicine & Hematology , University of the Witwatersrand, Wits Medical School, 3B22, 3rd Floor, 7 York Road, Parktown 2193, South AfricaLimited data exist on HIV-1 drug resistance patterns in South Africa following second-line protease-inhibitor containing regimen failure. This study examined drug resistance patterns emerging in 75 HIV-1 infected adults experiencing virologic failure on a second-line regimen containing 2 NRTI and lopinavir/ritonavir. Ninety six percent of patients (n=72) were infected with HIV-1 subtype C, two patients were infected with HIV-1 subtype D and one with HIV-1 subtype A1. Thirty nine percent (n=29) of patients had no resistance mutations in protease or reverse transcriptase suggesting that medication non-adherence was a major factor contributing to failure. Major lopinavir resistance mutations were infrequent (5 of 75; 7%), indicating that drug resistance is not the main barrier to future viral suppression.http://dx.doi.org/10.1155/2011/769627 |
| spellingShingle | Carole L. Wallis John W. Mellors Willem D. F. Venter Ian Sanne Wendy Stevens Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa AIDS Research and Treatment |
| title | Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa |
| title_full | Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa |
| title_fullStr | Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa |
| title_full_unstemmed | Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa |
| title_short | Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa |
| title_sort | protease inhibitor resistance is uncommon in hiv 1 subtype c infected patients on failing second line lopinavir r containing antiretroviral therapy in south africa |
| url | http://dx.doi.org/10.1155/2011/769627 |
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