Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases
Osteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammato...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7675437 |
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| _version_ | 1832551995636973568 |
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| author | Nausicaa Clemente Davide Raineri Giuseppe Cappellano Elena Boggio Francesco Favero Maria Felicia Soluri Chiara Dianzani Cristoforo Comi Umberto Dianzani Annalisa Chiocchetti |
| author_facet | Nausicaa Clemente Davide Raineri Giuseppe Cappellano Elena Boggio Francesco Favero Maria Felicia Soluri Chiara Dianzani Cristoforo Comi Umberto Dianzani Annalisa Chiocchetti |
| author_sort | Nausicaa Clemente |
| collection | DOAJ |
| description | Osteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammatory diseases. In some cases, the mechanisms of these effects have been described, but many aspects of the OPN function remain elusive. This is in part ascribable to the fact that OPN is a complex molecule with several posttranslational modifications and it may act as either an immobilized protein of the extracellular matrix or a soluble cytokine or an intracytoplasmic molecule by binding to a wide variety of molecules including crystals of calcium phosphate, several cell surface receptors, and intracytoplasmic molecules. This review describes the OPN structure, isoforms, and functions and its role in regulating the crosstalk between innate and adaptive immunity in autoimmune diseases. |
| format | Article |
| id | doaj-art-124f1c4186174d949cc57c57dba48f9d |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-124f1c4186174d949cc57c57dba48f9d2025-02-03T05:59:45ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/76754377675437Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune DiseasesNausicaa Clemente0Davide Raineri1Giuseppe Cappellano2Elena Boggio3Francesco Favero4Maria Felicia Soluri5Chiara Dianzani6Cristoforo Comi7Umberto Dianzani8Annalisa Chiocchetti9Department of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), “A. Avogadro” University of Piemonte Orientale (UPO), Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), “A. Avogadro” University of Piemonte Orientale (UPO), Novara, ItalyBiocenter, Division for Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), “A. Avogadro” University of Piemonte Orientale (UPO), Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), “A. Avogadro” University of Piemonte Orientale (UPO), Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), “A. Avogadro” University of Piemonte Orientale (UPO), Novara, ItalyDepartment of Drug Science and Technology, University of Torino, Torino, ItalyDepartment of Translational Medicine, Neurology Unit, “A. Avogadro” UPO, Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), “A. Avogadro” University of Piemonte Orientale (UPO), Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), “A. Avogadro” University of Piemonte Orientale (UPO), Novara, ItalyOsteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammatory diseases. In some cases, the mechanisms of these effects have been described, but many aspects of the OPN function remain elusive. This is in part ascribable to the fact that OPN is a complex molecule with several posttranslational modifications and it may act as either an immobilized protein of the extracellular matrix or a soluble cytokine or an intracytoplasmic molecule by binding to a wide variety of molecules including crystals of calcium phosphate, several cell surface receptors, and intracytoplasmic molecules. This review describes the OPN structure, isoforms, and functions and its role in regulating the crosstalk between innate and adaptive immunity in autoimmune diseases.http://dx.doi.org/10.1155/2016/7675437 |
| spellingShingle | Nausicaa Clemente Davide Raineri Giuseppe Cappellano Elena Boggio Francesco Favero Maria Felicia Soluri Chiara Dianzani Cristoforo Comi Umberto Dianzani Annalisa Chiocchetti Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases Journal of Immunology Research |
| title | Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases |
| title_full | Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases |
| title_fullStr | Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases |
| title_full_unstemmed | Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases |
| title_short | Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases |
| title_sort | osteopontin bridging innate and adaptive immunity in autoimmune diseases |
| url | http://dx.doi.org/10.1155/2016/7675437 |
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